Novel Apoptotic Evidence for Delayed Neuronal Death in the Hippocampal CA1 Pyramidal Cells After Transient Ischemia
نویسندگان
چکیده
منابع مشابه
The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.
A brief period of global brain ischemia, such as that induced by cardiac arrest or cardiopulmonary bypass surgery, causes cell death in vulnerable hippocampal CA1 pyramidal neurons days after reperfusion. Although numerous factors have been suggested to account for this phenomenon, the mechanisms underlying it are poorly understood. We describe a cell death signal called the PIDDosome, a protei...
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BACKGROUND AND PURPOSE p53-upregulated modulator of apoptosis (PUMA), a BH3-only member of the Bcl-2 protein family, is required for p53-dependent and -independent forms of apoptosis. PUMA localizes to mitochondria and interacts with antiapoptotic Bcl-2 and Bcl-X(L) or proapoptotic Bax in response to death stimuli. Although studies have shown that PUMA is associated with pathomechanisms of cere...
متن کاملSelective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia.
Transient global ischemia, as with cardiac arrest, causes loss of CA1 hippocampal neurons 2-4 d later, whereas nearby dentate gyrus (DG) neurons are relatively resistant. Whether differential astrocyte vulnerability in ischemic injury contributes to CA1 neuronal death is uncertain. Here, we find that CA1 astrocytes are more sensitive to ischemia than DG astrocytes. In rats subjected to transien...
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Ischemia/Reperfusion (I/R)-induced cerebral injury has been reported as a leading cause of deathand long-term disabilities. Hippocampus is an area which is more sensitive to be affected by I/Rand hypoxic conditions. Coenzyme Q10 is a strong antioxidant which plays a role in membranestabilization. This study aims to investigate the possible role of CoQ10 in ameliorating thehistomorphological cha...
متن کاملDelayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis.
The CA1 pyramidal neurons in the hippocampus are selectively vulnerable to transient ischemic damage. In experimental animals, the CA1 pyramidal neurons undergo cell death several days after brief forebrain ischemia. It remains, however, unknown whether this delayed neuronal death is necrosis or apoptosis. To investigate the degenerating processes of the CA1 pyramidal neurons in gerbil hippocam...
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ژورنال
عنوان ژورنال: Stroke
سال: 2000
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.31.1.231-e